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The Republic of Irelands hopes of qualifying automatically for Euro 2020 rest on next months home game with Denmark as soon as they lost in Switzerland.
Edimilson Fernandes and Haris Seferovic hit the goals although victory could have reserved the Irishs area.
Qualification will be secured by A triumph over the Danes on 18 November from Group D.
However, the Irish will be at conceding a penalty saved by Darren 24, without captain Seamus Coleman, who was sent .
After Tuesdays match had been jeopardized by rain, Switzerlands first-half stride afforded Fernandes hammered despite the efforts to keep the shot of Shane Duffy in the second in the final seconds and Benfica striker Seferovics 16th-minute target.
With the Republic changing in their early 3-5-2 formation they created strain however, the held firm to put themselves back after their defeat in Copenhagen on Saturday.
The Republic still best Group D goal difference from Denmark using Switzerland a stage behind but equally Danes and Swiss have games in hand, that come from out-of-contention sides Gibraltar and Georgia 15 November.
Slips by the Swiss against Georgia and in their final match in Gibraltar – or Denmark – a Republic win from the Danes in their final game will probably be sufficient to secure eligibility for McCarthys side.
If the Swiss select up four points in their past two matches the Irish would need to win by two objectives.
If this route fails, they may nevertheless have the fallback option of a place.
McCarthy passed a first start after his encouraging first-cap cameo at Saturday lure in Georgia to Brighton youngster Aaron Connolly but instead it had been the Breel Embolo who had been the offender in the first half that was critical of Borussia Monchengladbach.
With Embolo discovering space easily, he helped the Swiss split through the legs of Shane Duffy out a string of chances and Seferovics end from outside the box undid the clear method of holding out and frustrating the home of the Republic.
After the first half had been controlled by the Swiss the Republic rallied in the second phase but beyond using a Glenn Whelan shot blocked, had little to show in the method of chances.
Colemans dismissal came after he had been adjudged to have handled an Embolo shot in the 76th minute, which followed his yellow card with Arsenals Granit Xhaka for the angry exchange.
Substitute Ricardo Rodriguezs spot-kick was saved by randolph while Fabian Schar led before Fernandes objective against the Republic woodwork in the second half.
The display in Saturdays 0-0 draw in Georgia of the Republic came in for criticism and McCarthy opted for the formation that was modified as well as three modifications.
As Callum Robinson dropped out, with Preston midfielder Alan Browne brighton youngster Connolly partnered James Collins in assault.
As expected, Sheffield Uniteds Enda Stevens returned set up of Matt Doherty after suspension but had been part of a three-man defence alongside John Egan and Shane Duffy.
Regardless of Saturdays 1-0 defeat Denmark, Swiss boss Vladimir Petkovic chosen for an unchanged beginning line-up and his faith was rewarded because the home side quickly took control.
The signs were ominous for its people as Xhaka tested Randolph at the seventh minute before Swiss player of the year Seferovic blasted low through the legs of Duffy to the internet from just outside the box after Jeff Hendricks misdirected header.
At the other end, a Glenn Whelan corner was headed by Duffy direct in Ray keeper Yann Sommer before the break but it was a rare Republic target effort.
McCarthy introduced Callum ODowda to get striker Collins after abandoning his three at the back formation midway through the first half and it assisted the people produce some strain in the next quarter.
But the Swiss were ongoing to split with Randolph having to tilt more than a header then visiting Schars header come back off a post.
Connolly was substituted by Scott Hogan about 70 minutes before Colemans dismissal after conceding the penalty, because he picked up a yellow card.
The epic Randolph stretched to his left to keep out Rodriguezs spot-kick but can do nothing as Fernandes blasted in from close range in the final moment of injury-time despite the attempts of Duffy.
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