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As soon as they dropped in Switzerland, the Republic of Irelands hopes of qualifying for Euro 2020 remainder on next months home game with Denmark.
Edimilson Fernandes and Haris Seferovic hit the goals although victory would have booked the Irishs location.
Qualification will be secured by A win on the Danes on 18 November from Group D.
But the Irish will be in conceding a penalty superbly saved by Darren 24, without captain Seamus Coleman, who had been sent off.
After Tuesdays game had been jeopardized by rain, Switzerlands first-half stride afforded Fernandes hammered despite the efforts to keep the shot of Shane Duffy in the next in the final seconds and Benfica striker Seferovic goal.
With the Republic changing in their formation they created strain but the held company to place themselves back after their defeat in Copenhagen on Saturday.
The Republic still top Group D goal difference from Denmark using Switzerland a point behind but both the Danes and Swiss have games in hand, which come against Georgia and sides Gibraltar respectively 15 November.
Slips by the Korean against Georgia and at their final game in Gibraltar – or Denmark dropping to Gibraltar – a Republic win against the Danes in their match will probably be enough to secure qualification for McCarthys side.
The Irish would have to win by two objectives when the Swiss select up four points from their last two games.
They might nevertheless have the option of a location, if this route fails.
McCarthy given a first start to Brighton youngster Aaron Connolly following his cameo at Saturdays uninspiring lure in Georgia but rather it had been the Breel Embolo who was the most effective offender in the first half that was decisive of Borussia Monchengladbach.
With Embolo finding space readily, he assisted the split through the legs of Shane Duffy out a set of first-half opportunities and Seferovics ending from beyond the box undid the obvious method of carrying out and annoying the home of the Republic.
Following the first half had been controlled by the Swiss , the Republic rallied in the second phase but past using a Glenn Whelan shot blocked, had little to display in the manner of clearcut opportunities.
Colemans dismissal came after he was adjudged to have handled an Embolo shot in the 76th minute, which followed his yellow card with the Granit Xhaka of Arsenal.
While Fabian Schar also headed before Fernandes objective against the Republic woodwork from the second half substitute Ricardo Rodriguezs spot-kick was beautifully saved by randolph.
The display in Saturdays 0-0 draw in Georgia of the Republic came in for criticism and McCarthy opted for the formation as well as three changes.
As Callum Robinson dropped out, with Preston midfielder Alan Browne taking over from Conor 24, brighton youngster Connolly partnered James Collins in assault.
Sheffield Uniteds Enda Stevens returned set up of Matt Doherty after suspension but has been part of a three-man defence alongside John Egan and Shane Duffy as expected.
Despite Saturdays 1-0 defeat by Denmark, Swiss boss Vladimir Petkovic opted to get an unchanged beginning line-up as the home side quickly took control and his faith was rewarded.
The signs were ominous for the visitors as Xhaka tested Randolph in the seventh minute before Swiss player of this year Seferovic blasted low to the internet from just outside the box through the legs of Duffy after Jeff Hendrick defensive header.
In the other end, a Glenn Whelan corner was led by Duffy right just before the break but it was a Republic target attempt that was rare.
McCarthy introduced Callum ODowda to get striker Collins an after abandoning his three in the back formation midway through the half also it assisted the visitors produce some pressure in the next quarter.
Nevertheless, the Swiss were continuing to split out the better opportunities, with Randolph needing to tip within a header and then seeing Schars header come back off a post.
Connolly was substituted by Scott Hogan on 70 minutes shortly before Colemans dismissal because he picked up a yellow card after conceding the penalty.
The Randolph extended to keep out Rodriguezs spot-kick but can do nothing like Fernandes blasted in from close range despite Duffys attempts.
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